2026-10-26

Scientific computing increasingly relies on large language model-based agents for performance engineering tasks such as instrumentation, analysis, and workflow porting. However, agent effectiveness depends heavily on the surrounding harness, which typically relies on manually written skills and curated memory. This limits autonomous learning, forcing agents to repeatedly rediscover solutions rather than retain and reuse knowledge from prior executions. We introduce Phronix, a capability-centric learning paradigm that enables agentic harnesses to acquire, validate, and refine reusable capabilities from their own executions. Phronix operates through a predictor-validator-corrector loop: MCP tools and associated skills propose solutions, tool executions validate them, and observed outcomes refine the stored capabilities. It distills every observed interaction into a capability store and researches a failing task rather than abandoning it. First, such learned capabilities solve a recurring task on the first attempt in 93-95% of cases across every model, significantly reducing solution non-determinism and improving reliability. Second, Phronix turns an agent's own execution into 7.6-30.8 durable capabilities per task without user instruction, and creation falls below two once the needed capability exists. Third, warm-start runs consume only 0.38-0.40 million tokens per task, which is three to four times less than a single baseline attempt, while a cold-start costs no more than the baseline. On the 1000 Genome Pegasus workflow, instrumenting a production application for I/O performance analysis, Phronix passes all 11 correctness checks against six for the baseline harness, and also lifts the task solving rates of two cheaper models from 29% and 27% of SWE-bench tasks solved to 91% and 87%, respectively, matching the performance of the most expensive evaluated model.

Large language model (LLM)-based multi-agent systems (MAS) rely on role-specific prompts and execution models to solve complex tasks collaboratively. However, prompt optimization typically keeps model assignments fixed, leaving differences in role requirements and their associated inference costs outside the search. We present UniMASO, a Unified framework for heterogeneous Multi-Agent System Optimization through the joint adaptation of prompts and model assignments. UniMASO evaluates candidate updates through local, downstream, and global feedback, using cost-aware Pareto search to retain useful quality-cost trade-offs. Topology-aware co-evolution then coordinates these updates according to agent roles and dependencies. Cross-level trajectory memory further supplies historical successes and failures to guide subsequent optimization. Experiments on five benchmarks and five execution topologies show that UniMASO achieves competitive task performance at substantially lower deployment cost than the strongest homogeneous configurations. Under centralized execution, it improves the average score from 69.79 to 70.40 while reducing token-weighted deployment cost by 85.2% relative to DeepSeek-V4-Pro with MASPO. These results support joint prompt-model adaptation as an effective approach to efficient multi-agent collaboration. The code is available at https://github.com/Achilles008/UniMASO_main.

Agent harnesses repeatedly invoke reasoning after tool feedback, even when an earlier call has already fixed the next action. We introduce HarnessMM (Harness Minus Minus), a method for improving harness token efficiency through guarded decision reuse and recursive self-improvement (RSI). RSI iteratively refines companion harness configurations from training feedback, with validation selecting the configuration for deployment. A controller at the model-tool boundary reuses resolved decisions to replace later reasoning callbacks while actor weights remain fixed. Executable Decision Graphs store exact actions, literal arguments, causal dependencies, and public guards. Guarded Decision Reuse activates these persistent decisions from observed receipts; Certified Callback Substitution executes them through the native interface and records removal of the registered slow callback. New semantic decisions, unsupported evidence, and selector abstention invoke the original actor again. The representation restricts what feedback may change, while complete-task measurements establish quality and cost. On HumanEval, HarnessMM preserves Codex success at 90.82\% while reducing Tokens/task (k) from 66.72 to 47.02 (29.54\% saving). For DeepSeek Harness, success rises from 71.43\% to 85.71\% while Tokens/task (k) fall from 96.28 to 11.62 (87.93\% saving). A separate MBPP ablation measures 26.91\% lower cost than single-use graphs and 19.52\% lower cost than retained callbacks. These results establish guarded decision reuse as a practical way to reduce repeated reasoning in existing harnesses.

LLM-based multimodal emotion reasoning systems perform well on standard benchmarks, but improving them through instruction tuning can be computationally expensive. Agentic pipelines built from frozen models avoid this cost, but introduce a different challenge: when a prediction is wrong, the system must identify which agent or stage caused the error. We address this problem with an agentic framework for traceable multimodal emotion reasoning and prompt-space adaptation. Modality-specific perception agents analyze visual, acoustic, and lexical inputs and post evidence-cited observations to a shared board. An integration agent combines these observations with retrieved multimodal examples to produce an emotion description, label set, and supporting citations, while an MLLM critic can request one revision before the output is finalized. For incorrect predictions, a separate evidence-grounded verification stage applies deterministic checks to verify that cited evidence and references are valid, and an entailment check to determine whether the final claims are supported by that evidence. Detected failures are then grouped by the responsible component and failure type, converted into targeted prompt patches, and accepted only after validation on a held-out set. This adapts the agent prompts without updating model weights. On the MER2025 dataset, targeted prompt adaptation outperforms the frozen static pipeline on all four MLLMs, ranging from 2B to 38B parameters, and matches or outperforms undifferentiated reflection baselines on each of them: VideoLLaMA3-2B, Phi-3.5-vision-instruct, Qwen2.5-VL-7B-Instruct, and InternVL2.5-38B. It improves F-score by 0.6--2.2 points depending on the backbone, including an increase from 52.3 to 54.5 on Qwen2.5-VL-7B.

We present the framework of TACS-RF - a Tool-driven Agentic Circuit Synthesis of RF and mmWave modules. In this framework, a large-language-model (LLM) coding agent (Claude Opus 4.8) directly drives industry-standard electronic-design-automation (EDA) tools such as Cadence Virtuoso/Spectre, Calibre, Cadence EMX, and Ansys HFSS to design RF and mmWave modules. We validate the framework through the agentic design of a 240-251 GHz sub-THz transmitter in a 90 nm SiGe BiCMOS process. The agent semi-autonomously designed the sub-blocks including a 60 GHz push-push Colpitts VCO with second-harmonic extraction, multistage differential cascode power drivers, a push-push frequency doubler, a differential bowtie antenna, and all the interstage matching networks. The transmitter chain with parasitic-extracted devices and EM-verified passives delivers +5.1 to +6.3 dBm across an 11 GHz varactor-only tuning range, phase noise of -80 to -88 dBc/Hz at 1 MHz offset while consuming a DC power of 361 mW. We describe the agent-driven design flow and the resulting division of labor between human and agent, taking a step toward a "text-to-ASIC" future for designing RF/mmWave hardware.

LLM agents are increasingly deployed in collaborative settings where they pursue separate tasks while sharing resources and operating under review or oversight processes. Such settings create safety risks not only when agents are malicious, but also when they are simply trying to help. Prior work has largely studied adversarial or explicitly collusive behavior; we show that benign agents pursuing separate objectives can spontaneously cooperate in ways that bypass intended workflows. We call this the \emph{helpful agent problem}. We study long-horizon shared-resource environments in which agents sometimes depend on resources owned by their peers and cross-owner changes are normally mediated by a reviewer. When review becomes unavailable, agents begin making changes on one another's behalf despite having no shared reward or explicit incentive to cooperate. Crucially, these actions remain within each agent's local permissions while circumventing the system's intended oversight structure. We introduce \textsc{FavorBench}, a controlled benchmark with measurable downstream side effects, and adapt \textsc{CooperBench} to test the phenomenon in realistic repositories. Across two benchmarks and four models, we find that out-of-workflow favors emerge frequently. Further, in \textsc{FavorBench}, favors from at least three models cause significant harm to parties outside the interaction. These results reveal a distinct multi-agent safety challenge: cooperation itself can create pathways around system-level safeguards.

When LLM-powered agents interact, information is repeatedly shared, expanded, and forgotten, yet multi-agent evaluation typically focuses on final task outcomes. We study such interaction as claim-level information dynamics and propose RIVER, which decomposes agent outputs into atomic claims and evaluates three complementary dimensions: convergence, exploration, and retention. Convergence captures cross-agent claim correspondence and stance alignment; exploration captures semantic breadth and extension beyond the source; and retention tracks source preservation and the persistence of new claims across stages and lineages. We evaluate five interaction strategies on 40 controlled news-generation cases. Repeatedly pooled interaction promotes convergence but narrows the information space, whereas distributed relay yields broader, less shared information. Further comparisons show that method-specific constraints increase exploration while weakening convergence and retention. Our findings suggest that collective information dynamics are better explained by underlying information-flow mechanisms than by simple downstream performance.

Large language model (LLM) agents are increasingly capable of supporting scientific workflows, but their capabilities across diverse research activities remain difficult to assess systematically. Existing benchmarks often focus on selected scientific capabilities or task types, limiting a comprehensive characterization of scientific agents' strengths and weaknesses in realistic research workflows. We introduce SCI-AGENT-EXAM, a workflow-oriented benchmark comprising 120 expert-curated tasks across 11 scientific fields and 7 research task types defined by the Scientific Workflow Task Taxonomy (SWTT). Each task requires both executable artifacts (e.g., code and scripts) and textual artifacts (e.g., reports and explanations). To evaluate the heterogeneous task outputs, we develop a hybrid evaluation protocol combining deterministic programmatic verification for executable artifacts with a calibrated, expert-validated LLM-based judge for textual artifacts. Beyond outcome assessment, we analyze progress and solution stability along execution trajectories to characterize how agents reach their final results. Experiments with 10 frontier LLM agents reveal substantial performance gaps: GPT-6 Astra achieves the highest overall score of 80.9, yet only 26.0% of its runs exceed the 0.95 success threshold. Further analyses uncover distinct capability profiles across scientific task types and substantial variation in execution efficiency and stability. Our code and data are available at https://github.com/SKYLENAGE-AI/Sci-Agent-Exam.

Large language model agents that use tools could take on part of the electronic health record and desk work that occupies physicians' time, but in many hospitals the medical information systems run inside closed networks, so the model and the agent harness must also sit inside. We designed, implemented, and deployed LLENS, a clinical support AI agent platform that runs inside the closed network of Hokkaido University Hospital on one host with 8 NVIDIA H200 GPUs, the open-weight model Kimi K2.6 (~1 trillion parameters), and a web application rebuilt from Open WebUI. The harness has 10 components, including page image reading, full-text attachment input, a path-addressed document tree without a vector index, a network-isolated sandbox, artifact return, self-checking of generated output, subagents, and saved procedures. Kimi K2.6 was chosen from 3 open-weight candidates and scored 480/500 on the 2026 Japanese Medical Licensing Examination; it generated 119 tokens/s for one user and served 16 concurrent requests at 908 tokens/s in total. On 180 questions over hospital documents (3 seeds each), mean accuracy was 10.7% with no documents, 81.3% with fixed retrieval (top 10 chunks of one lexical search), and 97.2% with interactive access, in which the model reads with document tools and the sandbox (15.9 percentage points above fixed retrieval, 95% CI 10.9-21.3); the difference lay in filtering/counting questions (16.7% vs 87.8%). Five scenarios with synthetic data ran on combinations of the components: needlestick injury response, batch adverse event grading, scanned referral letter transcription, falls data aggregation and plotting, and investigation of 3 topics by subagents. The platform has run on the hospital network since September 14, 2026.

The rapid growth of microdramas has increased demand for high-quality script production. Long-form microdrama script generation with LLMs requires both diverse plot progression and long-range narrative coherence. Our observations reveal that candidate continuations increasingly concentrate on fewer narrative mechanisms as generation progresses, while conventional retrieval may reinforce trope reuse and overlook historical information essential to future plots. To address these challenges, we propose DraMaze, a multi-agent pipeline that explores diverse causal paths through trope memory-guided evolutionary tree search and mutation. It further constructs a Backward Narrative Dependency Tree to organize, retain, and retrieve historical memories based on future narrative goals. We also introduce MiDramaBench, a bilingual benchmark for evaluating script logic and creative quality across different script lengths, together with causal-pattern metrics for narrative repetition and diversity. Experiments show consistent improvements across three backbone LLMs. For 60-episode scripts of up to 60k words, DraMaze reduces causal-pattern repetition by 32.1% and achieves a Logic score of 82.5, outperforming the best-performing baseline by 8.5 points.

Although Large Language Models (LLMs) have demonstrated potential in clinical documentation, generating the rigorous, evidence-based reasoning required for unprecedented, atypical, and rare disease case reports remains a significant challenge. We present MedCaseAgent, an end-to-end agentic reasoning paradigm that bridges this gap by synthesizing publication-quality reports from unstructured clinical notes. MedCaseAgent leverages a hierarchical structure, integrating patient-level data mining with iterative, tool-integrated reasoning. By dynamically querying medical literature and knowledge bases, the agent maintains high clinical fidelity and assesses case novelty. The framework is inherently modular, supporting various backbone LLMs in a plug-and-play fashion. To facilitate this research, we release MedCase-150K, a large-scale multimodal clinical case-report corpus, and MedCase-Bench, a robust temporally held-out evaluation suite. We also introduce an open-source model post-trained from Qwen3.5-9B and optimized specifically for this task. Under both LLM-judged and rule-based evaluation, MedCaseAgent outperforms existing general-purpose and specialized medical LLMs and agents. Blinded expert reviews and ablations further support the system's clinical relevance and evidence grounding.

Hospitals regularly buy software that clinicians and patients depend on. Because these purchases are costly, hard to reverse and can affect patient care, buyers look for evidence of which peer institutions already use a product and which systems it connects to. This evidence is public but scattered across vendor websites, press releases and third-party pages. Language-model agents can now collect it at low cost, but the correctness of the extracted claims is difficult to establish, and a wrongly listed customer can mislead buyers and misrepresent an organisation. We present a pipeline that builds a knowledge graph of customer and integration relations from the open web under one rule: every edge must be supported by a verbatim quote from its source page. Pages come from a deterministic crawl of each vendor's site and a budgeted ReAct agent that searches the rest of the web. A permissive extractor proposes relations with quotes, and a layered grounding stage decides which to keep, using a referent step that reads the whole page when a quote names only one side, deterministic checks, and a panel of five model calls voting on nine criteria. On 61 vendors, the pipeline reaches 0.94 precision and 0.71 recall against a page-level key covering the 6,428 candidate relations proposed by its extractor, whose verdicts were drafted by one model and re-checked with a second. Against the golden reference, the marketplace's own curated list, it scores lower, but 89% of the relations it keeps that the reference lacks are stated on a page. A confidence score built from the panel's votes keeps more correct relations than the fixed rule at the same precision, and reaches 0.90 precision at 0.90 recall. We also discuss how narrow, bounded model calls, string-matched evidence and voting address long-context degradation and run-to-run variance.